9/9/2023 0 Comments Htf Digiter 1.0In addition to its function in iron transport, this protein may also have a physiologic role as granulocyte/pollen binding protein (GPBP) involved in the removal of certain organic matter/allergins from serum. The function of transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. It is synthesised in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. The antibody HTF-14 recognizes an epitope located in the N-terminal domain of human serum transferrin, a 77 kDa single polypeptide chain glycoprotein (member of the iron binding family of proteins). Iron/transferrin is essential in haemoglobin synthesis and for certain types of cell division. The iron is transported in blood and interstitial fluids to sites of use and disposal. It has a molecular weight of 77 kDa and a serum concentration range of 1800 to 2700 mg/L. Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins.
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